transgenic mouse การใช้

• Currently Swedish Mutation is widely used in Tg2573 transgenic mouse model of Alzheimer's Disease.
• A transgenic mouse model that is used to study the mechanism of disease in human patients.
• In 1989, he created the first transgenic mouse models for the study of in vivo mutagenesis.
• Some research has described transgenic mouse mutants that cause degeneration by prolonged activation of the phototransduction cascade.
• Modelling the disease in various types of animals, such as the transgenic mouse developed in 1996, enabled larger scale experiments.
• The other main effect the discovery of the Swedish mutation had was to provide one transgenic mouse model of Alzheimer's Disease.
• The company attracted worldwide headlines in February when it announced details concerning the first " transgenic mouse " engineered to contract Alzheimer's.
• Animal studies in the various transgenic mouse models of Alzheimer's disease had linked dietary DHA to decreases in amyloid plaques and tau.
• Nor are the latest results the first time a transgenic mouse mice has been produced that shows a hint of extra brainpower.
• Shin first generates a transgenic mouse for a given gene, and then analyzes the mouse at the molecular, cellular, physiological, and behavioral levels.
• VE-cadherin is indispensable for proper vascular development  there have been two transgenic mouse models of VE-cadherin deficiency, both embryonic lethal due to vascular defects.
• Regarding the mechanistic role of beta-catenin in cardiac hypertrophy, transgenic mouse studies have shown somewhat conflicting results regarding whether upregulation of beta-catenin is beneficial or detrimental.
• As part of her work she has also developed important biological tools, including a transgenic mouse that was the first animal model to overcome bacterial species-specificity.
• A single PCR assay is typically enough to genotype a transgenic mouse; the mouse is the mammalian model of choice for much of medical research today.
• In a transgenic mouse model of cancer, black cohosh did not increase incidence of primary breast cancer, but increased metastasis of pre-existing breast cancer to the lungs.
• His laboratory initially combined the use of transgenic mouse models and biochemical approaches to elucidate the mechanisms of gut epithelial development along the duodenal-colonic and crypt-villus axes.
• Over the next two decades, the LMRC expanded its work into the molecular genetics and cell biology of cancer, cardiovascular disease, aging and transgenic mouse models of disease.
• The transgenic mouse was created by combining a ?-galactosidase ( ?-gal ) reporter gene with a signal sequence and the transmembrane domain of the type I transmembrane protein CD4.
• A transgenic mouse has been created carrying a single copy of a mutant fibrillin-1, a mutation similar to that found in the human gene known to cause Marfan syndrome.
• The patents covering the Swedish mutation became highly contentious as the mutation was successfully inserted into mice providing the first example of a transgenic mouse model of Alzheimer's Disease.